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Abstract #2218

Divergent episodic memory networks among APOE alleles in cognitively normal elderly

Hao Shu 1,2 , Yongmei Shi 1 , Gang Chen 2 , Zan Wang 1 , Duan Liu 1 , Chunxian Yue 1 , B.Douglas Ward 2 , Wenjun Li 2 , Zhan Xu 2 , Guangyu Chen 2 , Qihao Guo 3 , Jun Xu 4 , Shi-Jiang Li 2 , and Zhijun Zhang 1

1 Department of Neurology, Affiliated ZhongDa Hospital, Neuropsychiatric Institute and Medical School of Southeast University, Nanjing, Jiangsu, China, 2 Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin, United States, 3 Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China, 4 Department of Neurology, Northern Jiangsu People's Hospital, Yangzhou, Jiangsu, China

The apoliprotein E (APOE) ε4 allele is a risk factor and the ε2 allele is a protective factor for elderly episodic memory (EM) deterioration. However, neural bases linking APOE alleles and EM function remain unclear. This study voxelwisely correlated the hippocampal functional connectivity strength and EM score. It demonstrated the divergence of hippocampal-related network among the three APOE alleles in the cognitively normal elderly subjects, which may contribute to the APOE polymorphism effects on brain activation and associated with their different AD risks.

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