Abstract #2221
A multi-scale MRI approach to investigate novel drug treatment strategies in mouse models of Alzheimer's disease
Holly Elizabeth Holmes 1 , Niall Colgan 1 , Ozama Ismail 1 , Da Ma 2,3 , Jack Wells 1 , Nicholas Powell 1,3 , James O'Callaghan 1 , Ian Harrison 1 , Manuel Jorge Cardoso 3 , Marc Modat 2 , Elizabeth MC Fisher 4 , Sebastian Ourselin 3 , Michael O'Neill 5 , Emily Catherine Collins 6 , and Mark F Lythgoe 2
1
Centre for Advanced Biomedical Imaging,
University College London, London, Greater London,
United Kingdom,
2
University
College London, London, Greater London, United Kingdom,
3
Centre
for Medical Image Computing, University College London,
London, Greater London, United Kingdom,
4
Department
of Neurodegenerative Diseases, University College
London, London, Greater London, United Kingdom,
5
Eli
Lilly & Co. Ltd, Windlesham, Surrey, United Kingdom,
6
Eli
Lilly & Company, Indianapolis, United States
A multi-scale MRI approach has been employed to
characterise the rTg4510 mouse model of Alzheimer's
disease, following early- and late-stage therapeutic
intervention
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