Abstract #2220
Brain plasticity in mild Alzheimers Disease. Effects of a computer-based cognitive training on functional connectivity
Francesco Barban 1 , Laura Serra 2 , Roberta Perri 3 , Roberta Annicchiarico 3 , Giovanni Augusto Carlesimo 3,4 , Matteo Mancini 5 , Fulvia Adriano 3 , Claudia Ricci 3 , Maria Giovanna Lombardi 3 , Mara Cercignani 6 , Lucia Fadda 3,4 , Carlo Caltagirone 3,4 , and Marco Bozzali 2
1
Clinical and Behavioral Neurology
Laboratory; Neuroimaging Laboratory, IRCCS S Lucia
Foundation, Rome, Rome, Italy,
2
Neuroimaging
Laboratory, IRCCS S Lucia Foundation, Rome, Rome, Italy,
3
Clinical
and Behavioral Neurology Laboratory, IRCCS S Lucia
Foundation, Rome, Rome, Italy,
4
Department
of Neuroscience, University of Rome "Tor Vergata", Rome,
Rome, Italy,
5
Department
of Engineering, University of Rome Roma Tre, Rome,
Rome, Italy,
6
Brighton
& Sussex Medical School, Clinical Imaging Sciences
Centre, University of Sussex, Brighton, Sussex, United
Kingdom
The aim of this study was to investigate, with resting
state-fMRI, the effects of a computerized cognitive
training vs. an active placebo condition on brain
networks of 19 mild Alzheimers Disease (mAD) patients
with a cross-over design. Comparing pre-post training
and placebo connectivity matrices, based on the
Automated Anatomical Labelling atlas, with Network-Based
Statistics, we found no placebo-related changes, whereas
during training emerged a significant increased
connectivity in brain regions crucial for memory and
decreased connectivity in regions probably mediating
compensational processes. We show for the first time a
of functional connectivity reorganization in mAD after
cognitive training.
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