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Abstract #2220

Brain plasticity in mild Alzheimers Disease. Effects of a computer-based cognitive training on functional connectivity

Francesco Barban 1 , Laura Serra 2 , Roberta Perri 3 , Roberta Annicchiarico 3 , Giovanni Augusto Carlesimo 3,4 , Matteo Mancini 5 , Fulvia Adriano 3 , Claudia Ricci 3 , Maria Giovanna Lombardi 3 , Mara Cercignani 6 , Lucia Fadda 3,4 , Carlo Caltagirone 3,4 , and Marco Bozzali 2

1 Clinical and Behavioral Neurology Laboratory; Neuroimaging Laboratory, IRCCS S Lucia Foundation, Rome, Rome, Italy, 2 Neuroimaging Laboratory, IRCCS S Lucia Foundation, Rome, Rome, Italy, 3 Clinical and Behavioral Neurology Laboratory, IRCCS S Lucia Foundation, Rome, Rome, Italy, 4 Department of Neuroscience, University of Rome "Tor Vergata", Rome, Rome, Italy, 5 Department of Engineering, University of Rome Roma Tre, Rome, Rome, Italy, 6 Brighton & Sussex Medical School, Clinical Imaging Sciences Centre, University of Sussex, Brighton, Sussex, United Kingdom

The aim of this study was to investigate, with resting state-fMRI, the effects of a computerized cognitive training vs. an active placebo condition on brain networks of 19 mild Alzheimers Disease (mAD) patients with a cross-over design. Comparing pre-post training and placebo connectivity matrices, based on the Automated Anatomical Labelling atlas, with Network-Based Statistics, we found no placebo-related changes, whereas during training emerged a significant increased connectivity in brain regions crucial for memory and decreased connectivity in regions probably mediating compensational processes. We show for the first time a of functional connectivity reorganization in mAD after cognitive training.

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