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Abstract #2224

Ex-vivo brain MR morphometric-pathologic investigation in a community cohort of older adults.

Junxiao Yu 1 , Aikaterini Kotrotsou 1 , Arnold M. Evia 1 , Julie A. Schneider 2 , Sue E. Leurgans 2 , David A. Bennett 2 , and Konstantinos Arfanakis 1

1 Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States, 2 Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, United States

Alzheimer's disease (AD) pathology commonly coexists with other age-related neuropathologies in the brain of older persons. Although brain atrophy is considered a biomarker of AD pathology, other neuropathologies may also lead to brain atrophy, and only a handful of studies with a number of limitations have combined brain MR volumetry/morphometry with measures of neuropathology obtained after death. Thus, the relation between brain atrophy and age-related neuropathology is not well-established. The purpose of this investigation was to assess the neuropathologic correlates of brain macrostructure by combining ex-vivo MRI RAVENS maps and pathology information on a large community cohort of older persons.

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