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Abstract #2225

Is the Superficial White Matter Important in Alzheimers Disease?

Owen R. Phillips 1,2 , Shantanu H. Joshi 3 , Fabrizio Piras 4 , Maria D. Orfei 4 , Mariangela Iorio 4 , Katherine L. Narr 3 , David W. Shattuck 3 , Carlo Caltagirone 1,2 , Gianfranco Spalletta 4 , and Margherita Di Paola 1,5

1 Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, roma, Lazio, Italy, 2 Neuroscience, University of Rome Tor Vergata, Rome, Roma, Italy, 3 Neurology, Ahmanson Lovelace Brain Mapping Center, Los Angeles, CA, United States, 4 Neuropsychiatry Laboratory, Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, Rome, Roma, Italy, 5 Human Studies, LUMSA University, Rome, Italy

The late myelinating superficial white matter (SWM) comprised of intracortical myelin and short-range association fibers has not received much attention in Alzheimers disease (AD) research. As the SWM is vulnerable to the normal effects of age, we hypothesized that it would be impaired in AD. We used a combined cortical pattern matching and DTI approach to measure mean diffusivity. We found significant increases in mean diffusivity across most of the brain in AD patients, which suggest the tissue is impaired. Given the unique cellular makeup and its importance in neuronal synchrony, the SWM may play an important role in AD.

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