Abstract #2227
Comparison of Relaxation, Magnetization Transfer, and Diffusion Tensor Measurements in the Hippocampal Formation between APP, PS1, and Control Mice
Sheryl L Herrera 1 , Heather Whittaker 2 , Shenghua Zhu 3 , Vanessa L Palmer 4 , Richard Buist 5 , Xin-Min Li 6 , Jonathan D Thiessen 7,8 , and Melanie Martin 9,10
1
Physics & Astronomy, University of Mantioba,
Winnipeg, Manitoba, Canada,
2
Biopsychology
program, University of Winnipeg, Winnipeg, Manitoba,
Canada,
3
Pharmacology
& Therapeutics, University of Mantioba, Winnipeg,
Manitoba, Canada,
4
Biomedical
Engineering, University of Mantioba, Winnipeg, Manitoba,
Canada,
5
Radiology,
University of Mantioba, Winnipeg, Manitoba, Canada,
6
Psychiatry,
University of Alberta, Edmonton, Alberta, Canada,
7
Imaging
Program, Lawson Health Research Institute, London,
Ontario, Canada,
8
Medical
Biophysics, Western University, London, Ontario, Canada,
9
Physics,
University of Winnipeg, Winnipeg, Manitoba, Canada,
10
Biomedical
Engineering, Physics &Astronomy, Pharmacology
&Therapeutics, Radiology, University of Mantioba,
Winnipeg, Manitoba, Canada
Quantifying structural changes in the hippocampal
formation (HF) and surrounding white matter with MRI can
improve both the diagnosis and understanding of AD. In
this study, anatomical details visible only in DEC maps
allowed ROIs to be defined and applied to all
quantitative MRI maps. Many significant differences were
found in MRI metrics between the transgenic mice when
compared with controls and in some cases between
transgenic strains themselves. Quantitative MRI methods
are useful for determining changes in tissue structure
and content within the HF and surrounding WM tracts
mouse models of AD. This is the first step toward
longitudinal
in
vivo
studies
correlated with histopathology.
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