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Abstract #2227

Comparison of Relaxation, Magnetization Transfer, and Diffusion Tensor Measurements in the Hippocampal Formation between APP, PS1, and Control Mice

Sheryl L Herrera 1 , Heather Whittaker 2 , Shenghua Zhu 3 , Vanessa L Palmer 4 , Richard Buist 5 , Xin-Min Li 6 , Jonathan D Thiessen 7,8 , and Melanie Martin 9,10

1 Physics & Astronomy, University of Mantioba, Winnipeg, Manitoba, Canada, 2 Biopsychology program, University of Winnipeg, Winnipeg, Manitoba, Canada, 3 Pharmacology & Therapeutics, University of Mantioba, Winnipeg, Manitoba, Canada, 4 Biomedical Engineering, University of Mantioba, Winnipeg, Manitoba, Canada, 5 Radiology, University of Mantioba, Winnipeg, Manitoba, Canada, 6 Psychiatry, University of Alberta, Edmonton, Alberta, Canada, 7 Imaging Program, Lawson Health Research Institute, London, Ontario, Canada, 8 Medical Biophysics, Western University, London, Ontario, Canada, 9 Physics, University of Winnipeg, Winnipeg, Manitoba, Canada, 10 Biomedical Engineering, Physics &Astronomy, Pharmacology &Therapeutics, Radiology, University of Mantioba, Winnipeg, Manitoba, Canada

Quantifying structural changes in the hippocampal formation (HF) and surrounding white matter with MRI can improve both the diagnosis and understanding of AD. In this study, anatomical details visible only in DEC maps allowed ROIs to be defined and applied to all quantitative MRI maps. Many significant differences were found in MRI metrics between the transgenic mice when compared with controls and in some cases between transgenic strains themselves. Quantitative MRI methods are useful for determining changes in tissue structure and content within the HF and surrounding WM tracts mouse models of AD. This is the first step toward longitudinal in vivo studies correlated with histopathology.

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