Abstract #2228
Improved Correlation of Iron to R2 and R2* in Alzheimers Disease-Affected White Matter
Christos Michaelides 1 , David J Lythgoe 1 , Harold G Parkes 2 , Claire Troakes 3 , Istvan Bodi 4 , Tina Geraki 5 , Amy H Herlihy 6 , and Po-Wah So 1
1
IOPPN, King's College London, London, United
Kingdom,
2
CR-UK
Clinical MR Research Group, Institute of Cancer
Research, Sutton, London, United Kingdom,
3
MRC
London Neurodegenerative Diseases Brain Bank, Department
of Clinical Neuroscience, IOPPN, King's College London,
London, United Kingdom,
4
Clinical
Neuropathology & London Neurodegenerative Diseases Brain
Bank, King's College London, London, United Kingdom,
5
Diamond
Light Source, Harwell Science and Innovation Campus,
Didcot, Oxfordshire, United Kingdom,
6
Agilent
Technologies, Yarnton, Oxfordshire, United Kingdom
Iron dysregulation may be a contributing factor to
neuronal cell death in Alzheimers disease. MR
relaxometry and MT measurements, in fixed post-mortem
human AD and control samples, were correlated with
direct iron assessment, using synchrotron radiation
X-ray fluorescence mapping. The correlation of iron
against MT or luxol fast blue staining were
significantly different between control and AD samples,
indicating a change in the relationship of iron and
myelin in AD. R2 and R2* values demonstrated greater
correlation to iron in AD-affected white matter than
control, potentially impacting the clinical relevance
for R2 and R2* relaxometry to assess iron in vivo.
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