Abstract #2230
The Background Brain Network Plays a Compensatory Role in Patients with Amnestic Mild Cognitive Impairment
Wutao Lou 1 , Lin Shi 2 , Defeng Wang 1 , Winnie CW Chu 1 , Vincent CT Mok 2 , Sheung-Tak Cheng 3,4 , and Linda CW Lam 5
1
Department of Imaging and Interventional
Radiology, The Chinese University of Hong Kong, Shatin,
NT, Hong Kong,
2
Department
of Medicine and Therapeutics, The Chinese University of
Hong Kong, Shatin, NT, Hong Kong,
3
Department
of Psychological Studies, Hong Kong Institute of
Education, Shatin, Hong Kong,
4
Center
for Psychosocial Health and Aging, Hong Kong Institute
of Education, Shatin, Hong Kong,
5
Department
of Psychiatry, The Chinese University of Hong Kong,
Shatin, NT, Hong Kong
The background brain activity was considered to reflect
the cognitive state of participants maintained the task.
In this study, the background network efficiency of the
working memory network of 17 aMCI patients and 19
controls were analyzed by using fMRI during a
visuospatial working memory task. The aMCI patients
showed increased local efficiency compared to normal
controls and suggested aMCI patients have to pay more
effort to complete the task due to memory impairment and
suggest the compensatory property of the background
network.
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