Abstract #2231
Simultaneous ASL/FDG-PET Imaging of Frontotemporal Dementia
Jing Zhang 1,2 , Elizabeth Finger 1,2 , Udunna Anazodo 2,3 , Julia MacKinley 2 , John Butler 2 , Frank Prato 2,3 , and Keith St Lawrence 2,3
1
Department of Clinical Neurological
Sciences, University of Western Ontario, London,
Ontario, Canada,
2
Lawson
Health Research Institute, London, Ontario, Canada,
3
Department
of Medical Biophysics, University of Western Ontario,
London, Ontario, Canada
This study compared the ability of ASL and FDG-PET to
distinguish FTD patients from controls. ASL and FDG-PET
images of 11 FTD patients and 10 age- and gender-matched
controls were acquired simultaneously. Cerebral blood
flow (CBF) and FDG-PET were positively correlated on the
normalized mean values across the gray matter (GM),
white matter, frontal and temporal lobes. Significant
group differences in both CBF and FDG uptake were found
in the GM and the frontal lobe. The results suggest that
ASL may be a promising alternative to FDG-PET for
detecting regional functional dysfunction associated
with FTD.
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