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Abstract #2231

Simultaneous ASL/FDG-PET Imaging of Frontotemporal Dementia

Jing Zhang 1,2 , Elizabeth Finger 1,2 , Udunna Anazodo 2,3 , Julia MacKinley 2 , John Butler 2 , Frank Prato 2,3 , and Keith St Lawrence 2,3

1 Department of Clinical Neurological Sciences, University of Western Ontario, London, Ontario, Canada, 2 Lawson Health Research Institute, London, Ontario, Canada, 3 Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada

This study compared the ability of ASL and FDG-PET to distinguish FTD patients from controls. ASL and FDG-PET images of 11 FTD patients and 10 age- and gender-matched controls were acquired simultaneously. Cerebral blood flow (CBF) and FDG-PET were positively correlated on the normalized mean values across the gray matter (GM), white matter, frontal and temporal lobes. Significant group differences in both CBF and FDG uptake were found in the GM and the frontal lobe. The results suggest that ASL may be a promising alternative to FDG-PET for detecting regional functional dysfunction associated with FTD.

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