Abstract #2232
Whole-Brain Correlation between Microstructural Alterations and Cognitive Performance of Alzheimer Disease Studied by Diffusion Kurtosis Imaging
Hongyan Ni 1 , Lixiang Yuan 2 , Yuanyuan Chen 3 , Man Sun 2 , Jianzhong Yin 1 , and Xu Yan 4
1
Tianjin First Central Hospital, Tianjin,
China,
2
First
Central Clinical College, Tianjin Medical University,
Tianjin, China,
3
Tianjin
University, Tianjin, China,
4
MR
Collaboration NE Asia, Siemens Healthcare, Shanghai,
China
To evaluate the correlation between the whole brain
non-Gaussian diffusion changes and cognitive performance
in Alzheimers disease (AD) patients, voxel-wise
multiple regression analyses were performed between the
diffusion kurtosis imaging (DKI) indices (MK, FA and MD)
and the Mini-Mental Status Examination (MMSE) scores
respectively. Results shown that indices of DKI,
especially MK detected more regions correlated between
the indices and the MMSE scores. Thus DKI may be a more
powerful compensatory technique in diagnosing and
monitoring the AD progression than conventional
diffusion tensor imaging (DTI).
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