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Abstract #2232

Whole-Brain Correlation between Microstructural Alterations and Cognitive Performance of Alzheimer Disease Studied by Diffusion Kurtosis Imaging

Hongyan Ni 1 , Lixiang Yuan 2 , Yuanyuan Chen 3 , Man Sun 2 , Jianzhong Yin 1 , and Xu Yan 4

1 Tianjin First Central Hospital, Tianjin, China, 2 First Central Clinical College, Tianjin Medical University, Tianjin, China, 3 Tianjin University, Tianjin, China, 4 MR Collaboration NE Asia, Siemens Healthcare, Shanghai, China

To evaluate the correlation between the whole brain non-Gaussian diffusion changes and cognitive performance in Alzheimers disease (AD) patients, voxel-wise multiple regression analyses were performed between the diffusion kurtosis imaging (DKI) indices (MK, FA and MD) and the Mini-Mental Status Examination (MMSE) scores respectively. Results shown that indices of DKI, especially MK detected more regions correlated between the indices and the MMSE scores. Thus DKI may be a more powerful compensatory technique in diagnosing and monitoring the AD progression than conventional diffusion tensor imaging (DTI).

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