Abstract #2233
Effect of Antiepileptic Treatment on Hippocampal Activity in Alzheimers Disease measured by ASL
Weiying Dai 1 , David C. Alsop 1 , and Daniel Z. Press 2
1
Radiology, Beth Israel Deaconess Medical
Center & Harvard Medical School, Boston, MA, United
States,
2
Neurology,
Beth Israel Deaconess Medical Center & Harvard Medical
School, Boston, MA, United States
Increased hippocampal perfusion in early AD has been
reported, but the underlying mechanism is still not
clear. We hypothesized that epileptiform activity occurs
in the hippocampus with AD and causes increased
perfusion. Here, we designed a placebo-controlled study
using an antiepileptic drug, Levetiracetam to modulate
epileptic activity of the hippocampus. Nine subjects
with AD were scanned following drug or placebo. We
observed increased rather than decreased hippocampal
perfusion with Levetiracetam. These findings suggest a
more complex behavior of drug and epileptic activity
effects in AD.
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