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Abstract #2234

Tensor-Based Morphometry reveals structural differences between Down syndrome and Alzheimers disease mouse model brains

Nick M Powell 1,2 , Holly E Holmes 2 , Da Ma 1,2 , Marc Modat 1 , Jorge Cardoso 1 , Frances K Wiseman 3 , Victor LJ Tybulewicz 4 , Elizabeth MC Fisher 3 , Mark F Lythgoe 2 , and Sebastien Ourselin 1

1 Centre for Medical Image Computing, University College London, London, England, United Kingdom, 2 Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom, 3 Department of Neurodegenerative Disease, Institute of Neurology, University College London, London, United Kingdom, 4 MRC National Institute for Medical Research, London, United Kingdom

We applied optimised protocols for high-resolution ex vivo MRI phenotyping of mouse brains, together with a fully automated image processing software pipeline, to perform tensor-based morphometry (TBM) on individual mouse models of Down syndrome and Alzheimers disease (the Tc1 and J20 models, respectively), as well as Tc1/J20 double mutants. In a comparison between Tc1/J20 and J20 brains, our analysis revealed significant differences in local morphology (volume) throughout the brain, including within the thalamus, olfactory bulbs and cerebellum. Our analysis highlights potential regions for later histology, and may inform behavioural investigations.

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