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Abstract #2236

The Improved Detection of 2-Hydroxyglutarate In Gliomas at 7 T Using High-Bandwidth Adiabatic Refocusing Pulses

Uzay E Emir 1 , Sarah Larkin 2 , Nick de Pennington 2 , Natalie Voets 1 , Puneet Plaha 3 , Richard Stacey 3 , James Mccullagh 4 , Stuart Clare 1 , Peter Jezzard 1 , Christopher Schofield 4 , Olaf Ansorge 2 , and Tom Cadoux-Hudson 3

1 FMRIB Centre, University of Oxford, Oxford, Oxfordshire, United Kingdom, 2 Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, Oxfordshire, United Kingdom, 3 Department of Neurosurgery, John Radcliffe Hospital, Oxford University Hospitals NHS Trust, Oxford, Oxfordshire, United Kingdom, 4 Department of Chemistry, University of Oxford, Oxford, Oxfordshire, United Kingdom

Mutations in IDH1 and IDH2 occur in up to 80% of a variety of glioma sub-types and lead to the production of MR detectable metabolite, 2-hydroxyglutarate (2-HG). In this abstract, we report results from a new acquisition protocol at 7T to detect 2-HG and the rest of the brain chemical profile in mutant IDH1/2 glioma patient with a higher sensitivity than has previously been achieved at clinical field. The new method at 7T is not only expected to increase diagnostic accuracy but also shorten the duration of the scan.

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