Abstract #2237
Characterizing regional heterogeneity of glioblastoma: regions representing metabolic aggression in enhancing and non-enhancing components
Natalie Rosella Boonzaier 1,2 , Timothy J Larkin 2,3 , Sarah Leir 3 , Laila A Mohsen 4 , Adam Young 3 , Victoria C Lupson 2 , and Stephen J Price 2,3
1
Department of Clinical Neurosciences,
University of Cambridge, Cambridge, Cambridgeshire,
United Kingdom,
2
Wolfson
Brain Imaging Centre, Addenbrooke's Hospital, Cambridge,
Cambridgeshire, United Kingdom,
3
Division
of Neurosurgery, University of Cambridge, Cambridge,
Cambridgeshire, United Kingdom,
4
Department
of Radiology, University of Cambridge, Cambridge, United
Kingdom
Glioblastomas are the most aggressive of the primary
brain tumours in adults. The intratumoral heterogeneity
that these lesions demonstrate is most likely the reason
behind treatment failure. Characterizing regional
heterogeneity, focusing on regions of combined diffusion
and perfusion properties with associated metabolically
aggressive profiles that go beyond the
contrast-enhancing lesion, and into the less-understood
non-enhancing component, may aid in understanding
treatment failure and inevitable recurrence, a
phenomenon that locally begins within the non-enhancing
component of the tumor.
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