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Abstract #2237

Characterizing regional heterogeneity of glioblastoma: regions representing metabolic aggression in enhancing and non-enhancing components

Natalie Rosella Boonzaier 1,2 , Timothy J Larkin 2,3 , Sarah Leir 3 , Laila A Mohsen 4 , Adam Young 3 , Victoria C Lupson 2 , and Stephen J Price 2,3

1 Department of Clinical Neurosciences, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom, 2 Wolfson Brain Imaging Centre, Addenbrooke's Hospital, Cambridge, Cambridgeshire, United Kingdom, 3 Division of Neurosurgery, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom, 4 Department of Radiology, University of Cambridge, Cambridge, United Kingdom

Glioblastomas are the most aggressive of the primary brain tumours in adults. The intratumoral heterogeneity that these lesions demonstrate is most likely the reason behind treatment failure. Characterizing regional heterogeneity, focusing on regions of combined diffusion and perfusion properties with associated metabolically aggressive profiles that go beyond the contrast-enhancing lesion, and into the less-understood non-enhancing component, may aid in understanding treatment failure and inevitable recurrence, a phenomenon that locally begins within the non-enhancing component of the tumor.

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