Abstract #2238
Longitudinal MRS imaging of 2-hydroxyglutarate in brain tumors in vivo
Sandeep Ganji 1 , Zhongxu An 1 , Dianne Mendelsohn 1 , Marco Pinho 1 , Edward Pan 1 , Kevin Choe 1 , Elizabeth Maher 1 , and Changho Choi 1
1
University of Texas Southwestern Medical
Center, Dallas, TX, United States
The present work reports first longitudinal MRS imaging
of 2-hydroxyglutarate (2HG) measures in brain tumors
using optimized PRESS TE = 97 ms at 3T. Metabolites
measures were measured in six clinically stable brain
tumors, over a period of 8 18 months. The coefficient
of variance (CoV) of 2HG was 1.1% over six subjects and
22 scans. The CoV of tCho, Glu and Gln were 3.5%, 11.1%
and 10.3%, respectively. The mean 2HG levels over the
tumor region remained within 0.2 to 0.8 mM across the
time points.
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