Meeting Banner
Abstract #2238

Longitudinal MRS imaging of 2-hydroxyglutarate in brain tumors in vivo

Sandeep Ganji 1 , Zhongxu An 1 , Dianne Mendelsohn 1 , Marco Pinho 1 , Edward Pan 1 , Kevin Choe 1 , Elizabeth Maher 1 , and Changho Choi 1

1 University of Texas Southwestern Medical Center, Dallas, TX, United States

The present work reports first longitudinal MRS imaging of 2-hydroxyglutarate (2HG) measures in brain tumors using optimized PRESS TE = 97 ms at 3T. Metabolites measures were measured in six clinically stable brain tumors, over a period of 8 18 months. The coefficient of variance (CoV) of 2HG was 1.1% over six subjects and 22 scans. The CoV of tCho, Glu and Gln were 3.5%, 11.1% and 10.3%, respectively. The mean 2HG levels over the tumor region remained within 0.2 to 0.8 mM across the time points.

This abstract and the presentation materials are available to members only; a login is required.

Join Here