Abstract #2241
Molecular subgroups of medulloblastoma identification by MR Spectroscopy
Stefan Bluml 1,2 , Ashley Margol 3,4 , Ashok Panigrahy 5 , Richard Sposto 3,6 , Rebekah Kennedy 3 , Marvin D Nelson 1 , and Shahab Asgharzadeh 3,4
1
Children's Hospital Los Angeles/USC, Los
Angeles, CA, United States,
2
Rudi
Schulte Research Institute, Santa Barbara, CA, United
States,
3
Children's
Hospital Los Angeles and Saban Research Institute, Los
Angeles, CA, United States,
4
Department
of Pediatrics, Keck School of Medicine, University of
Southern California, CA, United States,
5
Children's
Hospital of Pittsburgh, Pittsburgh, PA, United States,
6
Department
of Preventive Medicine, Keck School of Medicine,
University of Southern California, CA, United States
Medulloblastomas are the single most prevalent pediatric
brain tumor. Recently, analysis of tumor specimen
identified four molecular subtypes, with sonic hedgehog
(SHH) and WNT subtypes carrying significantly lower
risk for disease dissemination and poor outcome than
Group 3 or Group 4. In this retrospective study we
show that in vivo MR spectroscopy (MRS) can be used to
predict the molecular subtypes.
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