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Abstract #2242

Early Tumor Response to Radiochemotherapy using 1D PRESS and 2D Correlated Spectroscopy

Xi Long 1,2 , Daniel Ramirez-Gordillo 1 , Huijun Liao 1 , Ben Rowland 1 , Jong-Woo Lee 3 , Nils Arvold 4 , Patrick Wen 4 , Srinivasan Mukundan 1 , Raymond Huang 1 , and Alexander P Lin 1

1 Center for Clinical Spectroscopy, Brigham and Womens Hospital, Boston, MA, United States, 2 Radiology Department, Union Hospital, Tongji Medical School, Huazhong University of Science and Technology, Wuhan, Hubei, China, 3 Department of Neurology, Brigham and Womens Hospital, Boston, MA, United States, 4 Division of Neuro-Oncology, Brigham and Womens Hospital, Boston, MA, United States

Non-invasive and quantitative, magnetic resonance spectroscopy is ideally suited for treatment monitoring in brain gliomas. Recent studies have demonstrated the use of two-dimensional correlated spectroscopy (2D-COSY) for the evaluation of multiple metabolites. The goal of this study was to examine the efficacy of 2D-COSY compared to conventional MRS for the evaluation of brain tumors before and after radiochemotherapy. Our results demonstrate that 2D-COSY method provides similar results as 1D-MRS and can potentially provide additional metabolic information that may impact therapy.

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