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Abstract #2244

Glycine is a potential biomarker for malignant transformation in brain tumors

Changho Choi 1 , Sandeep Ganji 1 , Zhongxu An 1 , Dianne Mendelsohn 1 , Marco Pinho 1 , Edward Pan 1 , Kevin Choe 1 , and Elizabeth Maher 1

1 University of Texas Southwestern Medical Center, Dallas, Texas, United States

We report Gly elevation in brain tumors. Gly was measured, with PRESS TE=97ms at 3T, in five subjects with gliomas in vivo. In a WHO grade 3 oligodendroglioma patient, the Gly level was substantially higher in the tumor than in the contralateral. In three patients with glioblastomas, Gly was elevated by 10 fold or more. A longitudinal study in an oligoastrocytoma patient indicated that Gly increases with tumor progression. Our data suggest that Gly may be not only a useful biomarker for evaluating the tumor malignancy but also a noninvasive tool for monitoring the malignant transformation.

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