Abstract #2246
Molecular MRI Differentiation between Primary Central Nervous System Lymphoma (PCNSL) and High-grade Glioma (HGG) Using Endogenous Protein-based Amide Proton Transfer (APT) Signals
Shanshan Jiang 1,2 , Hao Yu 1 , Xianlong Wang 1 , Shilong Lu 1 , Yi Zhang 2 , Doon-Hoon Lee 2 , Hye-Young Heo 2 , Jinyuan Zhou 2 , and Zhibo Wen 1
1
Department of Radiology, Zhujiang Hospital
of Southern Medical University, Guangzhou, Guangdong,
China,
2
Department
of Radiology, Johns Hopkins University School of
Medicine, Baltimore, MD, United States
We explored the imaging features of PCNSL using APT
imaging of endogenous mobile proteins and peptides at 3
Tesla. Results showed that the PCNSL tumor core had
significantly higher APTW signal intensities, compared
to adjacent peritumoral edema and normal-appearing white
matter. The PCNSL tumor core had significantly lower
APTW signal intensities, intensity distribution, and
total CEST signal intensities, as well as significantly
higher MTR than the HGG core. APT imaging could provide
additional diagnostic information to differentiate PCNSL
from HGG non-invasively.
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