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Abstract #2246

Molecular MRI Differentiation between Primary Central Nervous System Lymphoma (PCNSL) and High-grade Glioma (HGG) Using Endogenous Protein-based Amide Proton Transfer (APT) Signals

Shanshan Jiang 1,2 , Hao Yu 1 , Xianlong Wang 1 , Shilong Lu 1 , Yi Zhang 2 , Doon-Hoon Lee 2 , Hye-Young Heo 2 , Jinyuan Zhou 2 , and Zhibo Wen 1

1 Department of Radiology, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, China, 2 Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States

We explored the imaging features of PCNSL using APT imaging of endogenous mobile proteins and peptides at 3 Tesla. Results showed that the PCNSL tumor core had significantly higher APTW signal intensities, compared to adjacent peritumoral edema and normal-appearing white matter. The PCNSL tumor core had significantly lower APTW signal intensities, intensity distribution, and total CEST signal intensities, as well as significantly higher MTR than the HGG core. APT imaging could provide additional diagnostic information to differentiate PCNSL from HGG non-invasively.

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