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Abstract #2248

Prediction of progression free survival at 6 months in high grade gliomas using pre-chemoradiotherapy MRI

Lawrence Kenning 1 , Martin Lowry 1 , Martin Pickles 1 , Chris Rowland-Hill 2 , Shailendra Achawal 2 , Chittoor Rajaraman 2 , and Lindsay Turnbull 1

1 Centre for MR Investigations, Hull York Medical School at University of Hull, Hull, United Kingdom, 2 Hull and East Yorkshire Hospitals NHS Trust, United Kingdom

We investigated whether MR parameters measured post-surgery prior to chemoradiotherapy could predict progression free survival in high grade gliomas. DTI, DSC and DCE data was acquired from 33 glioma patients prior to chemoradiotherapy. Mean and standard deviations were calculated for each parameter. Kaplan-Meier survival analysis was calculated using dichotomised parameter values. Results suggest that PK parameters derived from DCE-MRI and diffusion tensor metrics prior to adjuvant therapy predict progression-free survival. Elevated values of Ktrans, ve and vb were all significantly associated with a shorter progression-free survival interval. Blood products may prevent DSC from being clinically significant at this scan interval.

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