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Abstract #2249

Validation of the RANO criteria for quantifying therapeutic response of human brain tumors using computer assisted medical diagnosis (CAMD) technology

Simon Salinas 1 , Steve Lau 2 , Kate Drummond 3 , Christen Barras 2 , Pramit Phal 1,2 , Patricia Desmond 1,2 , and Bradford Moffat 1

1 The University of Melbourne, Melbourne, Victoria, Australia, 2 Radiology, Royal Melbourne Hospital, Melbourne, Victoria, Australia, 3 Neurosurgery, The University of Melbourne, Melbourne, Victoria, Australia

We evaluated the feasibility of automatic computer assisted RANO classification of glioblastoma response to therapy. We investigated the validity of the RANO criteria in 31 patients undergoing chemo and radiation therapy. It was found that the RANO assessment could be reliably performed in less than 10 minutes per patient, using a dedicated graphical user interface. RANO classification was found to significantly correlate with patient survival with stable disease patients having a significant survival advantage (41 weeks p=0.04) compared to progressive disease patients. This graphical user interface and the validation of the criteria could pave the way for clinical translation.

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