Abstract #2249
Validation of the RANO criteria for quantifying therapeutic response of human brain tumors using computer assisted medical diagnosis (CAMD) technology
Simon Salinas 1 , Steve Lau 2 , Kate Drummond 3 , Christen Barras 2 , Pramit Phal 1,2 , Patricia Desmond 1,2 , and Bradford Moffat 1
1
The University of Melbourne, Melbourne,
Victoria, Australia,
2
Radiology,
Royal Melbourne Hospital, Melbourne, Victoria,
Australia,
3
Neurosurgery,
The University of Melbourne, Melbourne, Victoria,
Australia
We evaluated the feasibility of automatic computer
assisted RANO classification of glioblastoma response to
therapy. We investigated the validity of the RANO
criteria in 31 patients undergoing chemo and radiation
therapy. It was found that the RANO assessment could be
reliably performed in less than 10 minutes per patient,
using a dedicated graphical user interface. RANO
classification was found to significantly correlate with
patient survival with stable disease patients having a
significant survival advantage (41 weeks p=0.04)
compared to progressive disease patients. This graphical
user interface and the validation of the criteria could
pave the way for clinical translation.
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