Abstract #2260

IVIM-MRI Reproducibility for Functional Parametric Mapping of Treatment Response in High-Grade Glioma

Jack T Skinner ^1,2 , Paul L Moots ³ , Adrienne N Dula ^1,2 , and C Chad Quarles ^1,2

¹ Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, ² Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, ³ Neurology, Vanderbilt University Medical Center, Nashville, TN, United States

Intravoxel incoherent motion (IVIM)-MRI has been shown to measure brain tumor perfusion. The effect of longitudinal treatment on IVIM estimates in glioma, however, is unknown. To elucidate these effects, functional IVIM mapping was performed. To implement this technique, IVIM reproducibility was first established in healthy subjects. f and D were found to be reproducible (wCV < 10%) while D* was less reproducible (wCV approximately equal

16%). In patients, functional maps revealed a predominate increase in f with treatment. Though a robust decrease in D was observed, ADC remained relatively unchanged. Functional IVIM mapping may, therefore, help identify local regions of tumor progression or treatment effect.

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