Abstract #2268
in a Rat Model of Cerebral Tumor, Exudate Flux is Controlled by Peritumoral Compression
James R. Ewing 1 , Stephen L. Brown 2 , Madhava P. Aryal 1 , Kelly Ann Keenan 3 , Rasha M. Elmghirbi 4 , Swayamprav Panda 1 , Hassan Bagher-Ebadian 1 , and Tavarekere N. Nagaraja 3
1
Neurology, Henry Ford Health System,
Detroit, MI, United States,
2
Radiation
Oncology, Henry Ford Health System, Detroit, MI, United
States,
3
Anesthesiology,
Henry Ford Health System, Detroit, MI, United States,
4
Physics,
Oakland University, Rochester, MI, United States
In a U251 rat model of cerebral tumor, extracellular
volume was measured in the tumor, and in the normal
tissue surround of the tumor via an innovative
application of the Logan plot. Similarly, tumor exudate
flux through the boundary of the tumor was measure via
an application of a Patlak plot. Extracellular volume in
the normal rim of the tumor was strongly decreased,
implying compression in the tumor periphery. In 18
animals, tumor exudate flux was strongly dependent
(R2=0.9) on compression of peritumoral tissue.
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