Abstract #2272
Design of a 3D-Phantom to evaluate optimized imaging parameters for Time-of-Flight Angiography in mouse glioblastoma models
Carly Warren 1 , Michael Bock 1 , Jochen Leupold 1 , and Wilfried Reichardt 1,2
1
Department of Radiology Medical Physics,
Universitiy Medical Center Freiburg, Freiburg, Germany,
2
German
Cancer Consortium (DKTK), German Cancer Center (DKFZ),
Heidelberg, Germany
Glioblastomas are very heterogeneous and diffusely
growing brain tumors. They initiate and maintain
angiogenesis during their growth. To assess whether a
novel therapeutic drug changes the vascular
architecture, non-invasive imaging methods to study
changes of the neo-angiogenic vasculature are urgently
needed. Time-of-Flight (TOF) is an imaging technique
used in Magnetic Resonance Angiography (MRA) that is
able to depict pathologic vasculature based on the flow
of blood. In this study a 3D-phantom is constructed to
simulate the vascular tree in a mouse to analyze the
effects of TOF-MRA sequence parameters on the signal
intensity in the vicinity of a glioblastoma.
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