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Abstract #2272

Design of a 3D-Phantom to evaluate optimized imaging parameters for Time-of-Flight Angiography in mouse glioblastoma models

Carly Warren 1 , Michael Bock 1 , Jochen Leupold 1 , and Wilfried Reichardt 1,2

1 Department of Radiology Medical Physics, Universitiy Medical Center Freiburg, Freiburg, Germany, 2 German Cancer Consortium (DKTK), German Cancer Center (DKFZ), Heidelberg, Germany

Glioblastomas are very heterogeneous and diffusely growing brain tumors. They initiate and maintain angiogenesis during their growth. To assess whether a novel therapeutic drug changes the vascular architecture, non-invasive imaging methods to study changes of the neo-angiogenic vasculature are urgently needed. Time-of-Flight (TOF) is an imaging technique used in Magnetic Resonance Angiography (MRA) that is able to depict pathologic vasculature based on the flow of blood. In this study a 3D-phantom is constructed to simulate the vascular tree in a mouse to analyze the effects of TOF-MRA sequence parameters on the signal intensity in the vicinity of a glioblastoma.

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