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Abstract #2271

Glioma grading using standardized rCBV depends on tumor type

Mona M Al-Gizawiy 1 , Melissa A Prah 1 , Wade M Mueller 2 , and Kathleen M Schmainda 1,3

1 Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States, 2 Neurosurgery, Medical College of Wisconsin, Wisconsin, United States, 3 Biophysics, Medical College of Wisconsin, Wisconsin, United States

Histopathology remains the gold standard for the diagnosis of brain tumors, even though MR imaging provides invaluable additional information on tumor behavior. Histopathological findings of 157 brain tissue specimens from 34 adult patients were matched to intraoperative surgical navigation snapshots of tissue collection sites. Preoperative leakage-corrected sRCBV differentiated between astrocytoma and oligodendroglioma grades, but this ability to distinguish between the grades was lost when different glioma types were combined for analysis. We present evidence that histologically different gliomas are also biologically distinct, characterized by significant differences in perfusion and diffusion measures, reinforcing the important role of sRCBV in glioma characterization.

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