Abstract #2271
Glioma grading using standardized rCBV depends on tumor type
Mona M Al-Gizawiy 1 , Melissa A Prah 1 , Wade M Mueller 2 , and Kathleen M Schmainda 1,3
1
Radiology, Medical College of Wisconsin,
Milwaukee, Wisconsin, United States,
2
Neurosurgery,
Medical College of Wisconsin, Wisconsin, United States,
3
Biophysics,
Medical College of Wisconsin, Wisconsin, United States
Histopathology remains the gold standard for the
diagnosis of brain tumors, even though MR imaging
provides invaluable additional information on tumor
behavior. Histopathological findings of 157 brain tissue
specimens from 34 adult patients were matched to
intraoperative surgical navigation snapshots of tissue
collection sites. Preoperative leakage-corrected sRCBV
differentiated between astrocytoma and oligodendroglioma
grades, but this ability to distinguish between the
grades was lost when different glioma types were
combined for analysis. We present evidence that
histologically different gliomas are also biologically
distinct, characterized by significant differences in
perfusion and diffusion measures, reinforcing the
important role of sRCBV in glioma characterization.
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