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Abstract #2270

DCE-MRI reveals increased peritumoral fluid flow in brain metastases after SRS

Tord Hompland 1 , Catherine Coolens 1 , Brandon Driscoll 1 , Warren Foltz 1 , Cynthia Menard 1 , David A. Jaffray 1,2 , and Caroline Chung 1

1 Princess Margaret Cancer Centre, Toronto, Ontario, Canada, 2 TECHNA Institute/University Health Network, ontario, Canada

Here we communicate a method for measuring interstitial fluid flow in brain metastases, a potential tool to noninvasively measure changes in IFP. With this method we were able to show an increased peritumoral fluid flow 2 days following stereotactic surgery, most likely caused by an increase in tumor vasculature permeability and subsequent increase in IFP. Interstitial fluid flow also correlated with peritumoral edema. Interestingly, we also show that the fluid flow induced contrast agent transport can lead to misinterpretations of tumor volume measured by DCE-MRI depending on the time interval between injection and contrast-enhanced image acquisition.

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