Abstract #2274
Pretreatment Dynamic Contrast-Enhanced MR Imaging in Glioblastoma : Correlation Study with Genetic Profiles
Yoon Seong Choi 1 , Tyler Hyungtaek Rim 2 , Mina Park 1 , Ho-Joon Lee 1 , Sung Soo Ahn 1 , Jinna Kim 1 , and Seung-Koo Lee 1
1
department of radiology, Yonsei university
college of medicine, Seoul, Seoul, Korea,
2
department
of ophthalmology, Yonsei university college of medicine,
Seoul, Seoul, Korea
We investigated the usefulness of preoperative DCE-MRI
in predicting three major genetic profiles of
glioblastomas including EGFR, p53 and Ki-67, using
histogram analysis. We found that Ktrans values were
higher in EGFR positive tumors than EGFR negative
tumors, and that Ktrans values were negatively
correlated with p53 expression, thus associated with
genetic profiles implicating poor prognosis in
glioblastomas. We suggest that DCE-MRI might be useful
in predicting genetic profiles associated with
prognosis, and determining appropriate treatment
strategy in patients with glioblastoma.
This abstract and the presentation materials are available to members only;
a login is required.
Join Here
