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Abstract #2274

Pretreatment Dynamic Contrast-Enhanced MR Imaging in Glioblastoma : Correlation Study with Genetic Profiles

Yoon Seong Choi 1 , Tyler Hyungtaek Rim 2 , Mina Park 1 , Ho-Joon Lee 1 , Sung Soo Ahn 1 , Jinna Kim 1 , and Seung-Koo Lee 1

1 department of radiology, Yonsei university college of medicine, Seoul, Seoul, Korea, 2 department of ophthalmology, Yonsei university college of medicine, Seoul, Seoul, Korea

We investigated the usefulness of preoperative DCE-MRI in predicting three major genetic profiles of glioblastomas including EGFR, p53 and Ki-67, using histogram analysis. We found that Ktrans values were higher in EGFR positive tumors than EGFR negative tumors, and that Ktrans values were negatively correlated with p53 expression, thus associated with genetic profiles implicating poor prognosis in glioblastomas. We suggest that DCE-MRI might be useful in predicting genetic profiles associated with prognosis, and determining appropriate treatment strategy in patients with glioblastoma.

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