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Abstract #2275

Understanding the Mechanism of Contrast Enhancement in Brain Tumors and Infections Through Dynamic Contrast Enhanced MRI

Mudit Gupta 1 , Prativa Sahoo 2 , Ritu Tyagi 1 , Rana Patir 3 , Sandeep Vaishya 4 , Neeraj Prakash 4 , Indrajit Saha 2 , and Rakesh Kumar Gupta 1

1 Radiology, Fortis Institute, Gurgaon, Haryana, India, 2 Philips Healthcare, Gurgaon, India, 3 Neurosurgery, Fortis Institute, Gurgaon, India, 4 Pathology, Fortis Institute, Gurgaon, India

While conventional post-contrast MRI demonstrates pathologies, perfusion MRI does it better. We evaluated the relative contributions of plasma volume (rPV) and extracellular, extravascular volume (rEV) to the contrast enhancement of intracranial lesions -- gliomas and neurocysticerosis (NCC). Intra-group comparison revealed significantly higher rEV than rPV in NCC and no significant difference in tumors. Inter-group comparison demonstrated significantly higher rPV in gliomas vis--vis higher rEV in NCC. We have demonstrated that breakdown of blood-brain barrier is the predominant pathology in enhancing NCC vis--vis neoangiogenesis in enhancing gliomas.

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