Abstract #2275
Understanding the Mechanism of Contrast Enhancement in Brain Tumors and Infections Through Dynamic Contrast Enhanced MRI
Mudit Gupta 1 , Prativa Sahoo 2 , Ritu Tyagi 1 , Rana Patir 3 , Sandeep Vaishya 4 , Neeraj Prakash 4 , Indrajit Saha 2 , and Rakesh Kumar Gupta 1
1
Radiology, Fortis Institute, Gurgaon,
Haryana, India,
2
Philips
Healthcare, Gurgaon, India,
3
Neurosurgery,
Fortis Institute, Gurgaon, India,
4
Pathology,
Fortis Institute, Gurgaon, India
While conventional post-contrast MRI demonstrates
pathologies, perfusion MRI does it better. We evaluated
the relative contributions of plasma volume (rPV) and
extracellular, extravascular volume (rEV) to the
contrast enhancement of intracranial lesions -- gliomas
and neurocysticerosis (NCC). Intra-group comparison
revealed significantly higher rEV than rPV in NCC and no
significant difference in tumors. Inter-group comparison
demonstrated significantly higher rPV in gliomas
vis--vis higher rEV in NCC. We have demonstrated that
breakdown of blood-brain barrier is the predominant
pathology in enhancing NCC vis--vis neoangiogenesis in
enhancing gliomas.
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