Abstract #2277
The complementary value of arterial spin labeling next to contrast-enhanced MRI in the diagnosis of brain tumor invasion in mouse models
Houshang Amiri 1,2 , Anna C. Navis 3 , Tom Peeters 1 , William P. Leenders 3 , and Arend Heerschap 1
1
Department of Radiology, Radboud University
Medical Center, Nijmegen, Gelderland, Netherlands,
2
Department
of Cognitive Neuroscience, Radboud University Medical
Center, Nijmegen, Gelderland, Netherlands,
3
Department
of Pathology, Radboud University Medical Center,
Nijmegen, Gelderland, Netherlands
Arterial spin labeling (ASL) provides valuable
information on cerebral blood flow (CBF) by using blood
water molecules as an endogenous tracer. We aimed to
first evaluate ASL to diagnose diffuse infiltrative
glioma in well characterized xenografts mouse models and
then to combine it with the commonly used method, i.e.
contrast-enhanced (CE) MRI. We showed that ASL has
potentials to detect diffuse infiltrative parts of
tumors and therefore could be considered as a
complementary value to the CE MRI by which compact
growing parts of tumors are diagnosed.
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