Abstract #2281
Resting State Functional Connectivity of the Hippocampus in Patients Receiving Radiation Therapy for Extra-Axial Tumors
Marc C Mabray 1 , Igor J Barani 2 , Suresh E Joel 3 , Rakesh Mullick 3 , and Soonmee Cha 1
1
Radiology and Biomedical Imaging, University
of California San Francisco, San Francisco, CA, United
States,
2
Radiation
Oncology, University of California San Francisco, San
Francisco, CA, United States,
3
General
Electric Global Research, Bangalore, Karnataka, India
We aim to study the effects of radiation therapy on
resting state functional connectivity. In this study we
evaluated hippocampal functional connectivity in
patients with extra-axial tumors receiving focal
radiation therapy. We found decreased functional
connectivity of the right hippocampus to the right
putamen post-radiation therapy as compared to
pre-radiation therapy. Further investigation into the
effects of radiation dose to the hippocampus on
functional connectivity and correlation with
neurocognitive function is warranted. This may have
implications for radiation therapy planning and provide
insight into radiation related neurocognitive
dysfunction.
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