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Abstract #2284

Morphological and Microstructural Changes in the Eye and the Brain in an Experimental Glaucoma Model Induced by Crosslinking Hydrogel Injection

Leon C. Ho 1,2 , Ian P. Conner 3,4 , Xiao-Ling Yang 1,3 , Yolandi van der Merwe 1,4 , Yu Yu 5 , Christopher K. Leung 6,7 , Ian A. Sigal 3,4 , Ed X. Wu 2 , Seong-Gi Kim 1,8 , Gadi Wollstein 3 , Joel S. Schuman 3,4 , and Kevin C. Chan 1,3

1 Neuroimaging Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania, United States, 2 Department of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam, Hong Kong, China, 3 Department of Ophthalmology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States, 4 Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States, 5 Division of Biomedical Engineering, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China, 6 University Eye Center, Hong Kong Eye Hospital, Hong Kong, China, 7 Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China, 8 Center for Neuroscience Imaging Research, Institute for Basic Science, Sungkyunkwan University, Suwon, Korea

Glaucoma is the second leading cause of blindness in the world and is an irreversible neurodegenerative disease of the visual system. To date, limited models have been available to provide sustained intraocular pressure elevation while keeping a clear visual axis for normal visual input to the eye. In this study, we characterized a novel experimental glaucoma model in rats using a crosslinking hydrogel that gives sustained intraocular pressure elevation and a transparent medium after intracameral injection. In vivo anatomical MRI, magic angle-enhanced MRI and diffusion tensor imaging were employed to determine the morphological and microstructural changes in the whole eye and the brain in this model.

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