Abstract #2284
Morphological and Microstructural Changes in the Eye and the Brain in an Experimental Glaucoma Model Induced by Crosslinking Hydrogel Injection
Leon C. Ho 1,2 , Ian P. Conner 3,4 , Xiao-Ling Yang 1,3 , Yolandi van der Merwe 1,4 , Yu Yu 5 , Christopher K. Leung 6,7 , Ian A. Sigal 3,4 , Ed X. Wu 2 , Seong-Gi Kim 1,8 , Gadi Wollstein 3 , Joel S. Schuman 3,4 , and Kevin C. Chan 1,3
1
Neuroimaging Laboratory, University of
Pittsburgh, Pittsburgh, Pennsylvania, United States,
2
Department
of Electrical and Electronic Engineering, The University
of Hong Kong, Pokfulam, Hong Kong, China,
3
Department
of Ophthalmology, School of Medicine, University of
Pittsburgh, Pittsburgh, Pennsylvania, United States,
4
Department
of Bioengineering, Swanson School of Engineering,
University of Pittsburgh, Pittsburgh, Pennsylvania,
United States,
5
Division
of Biomedical Engineering, Hong Kong University of
Science and Technology, Clear Water Bay, Hong Kong,
China,
6
University
Eye Center, Hong Kong Eye Hospital, Hong Kong, China,
7
Department
of Ophthalmology and Visual Sciences, The Chinese
University of Hong Kong, Hong Kong, China,
8
Center
for Neuroscience Imaging Research, Institute for Basic
Science, Sungkyunkwan University, Suwon, Korea
Glaucoma is the second leading cause of blindness in the
world and is an irreversible neurodegenerative disease
of the visual system. To date, limited models have been
available to provide sustained intraocular pressure
elevation while keeping a clear visual axis for normal
visual input to the eye. In this study, we characterized
a novel experimental glaucoma model in rats using a
crosslinking hydrogel that gives sustained intraocular
pressure elevation and a transparent medium after
intracameral injection. In vivo anatomical MRI, magic
angle-enhanced MRI and diffusion tensor imaging were
employed to determine the morphological and
microstructural changes in the whole eye and the brain
in this model.
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