Optimization of sample preparation for MRI of formaldehyde-fixed brains
Yann Leprince 1,2 , Benot Schmitt 1 , lodie Chaillou 3 , Christophe Destrieux 4 , Laurent Barantin 4 , Alexandre Vignaud 1 , Denis Rivire 1 , and Cyril Poupon 1
NeuroSpin, CEA, Saclay, France,
Paris-Sud, Orsay, France,
Franois-Rabelais, Tours, France
MRI of post-mortem brain specimen is often used because
it allows high-resolution imaging thanks to long
acquisitions times and the absence of movement. It also
allows correlation with histological examination of the
tissue. However, fixation with formaldehyde modifies the
relaxivity and diffusion properties of tissue. This
study investigates the kinetics of these modifications,
and their reversibility when free formaldehyde is washed
out of the tissue by soaking in saline solution.
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