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Abstract #2283

Optimization of sample preparation for MRI of formaldehyde-fixed brains

Yann Leprince 1,2 , Benot Schmitt 1 , lodie Chaillou 3 , Christophe Destrieux 4 , Laurent Barantin 4 , Alexandre Vignaud 1 , Denis Rivire 1 , and Cyril Poupon 1

1 NeuroSpin, CEA, Saclay, France, 2 Universit Paris-Sud, Orsay, France, 3 INRA, Tours, France, 4 Universit Franois-Rabelais, Tours, France

MRI of post-mortem brain specimen is often used because it allows high-resolution imaging thanks to long acquisitions times and the absence of movement. It also allows correlation with histological examination of the tissue. However, fixation with formaldehyde modifies the relaxivity and diffusion properties of tissue. This study investigates the kinetics of these modifications, and their reversibility when free formaldehyde is washed out of the tissue by soaking in saline solution.

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