Abstract #2283
Optimization of sample preparation for MRI of formaldehyde-fixed brains
Yann Leprince 1,2 , Benot Schmitt 1 , lodie Chaillou 3 , Christophe Destrieux 4 , Laurent Barantin 4 , Alexandre Vignaud 1 , Denis Rivire 1 , and Cyril Poupon 1
1
NeuroSpin, CEA, Saclay, France,
2
Universit
Paris-Sud, Orsay, France,
3
INRA,
Tours, France,
4
Universit
Franois-Rabelais, Tours, France
MRI of post-mortem brain specimen is often used because
it allows high-resolution imaging thanks to long
acquisitions times and the absence of movement. It also
allows correlation with histological examination of the
tissue. However, fixation with formaldehyde modifies the
relaxivity and diffusion properties of tissue. This
study investigates the kinetics of these modifications,
and their reversibility when free formaldehyde is washed
out of the tissue by soaking in saline solution.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
