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Abstract #2297

A Study of MS Based on a Fusion Quantitative Analysis Model of DTI

Heather Ting Ma 1,2 , Pengfei Yang 1 , Chenfei Ye 1 , Jun Wu 3 , Xuhui Chen 3 , and Jinbo Ma 1

1 Department of Electronic and Information Engineering, Harbin Institute of Technology Shenzhen Graduate School, Shenzhen, Guangdong, China, 2 Radiology Department, Johns Hopkins University, Baltimore, MD, United States, 3 Department of Neurology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China

This study aimed at exploring lesion detection of multiple sclerosis (MS) which couldnt be seen on conventional MRI. The whole brain voxel-by-voxel DTI analysis was performed on clinical data with a fusion quantitative analysis model, which was based on TBSS and VBA method with an anisotropic filter. Quantitative comparison result for the fusion model demonstrated statistically significant reduction of FA values in all MS patients compared with controls. The lesions mainly located in corpus callosum, corticospinal tract, occipital lobe, and optic tract. The optic tract lesions may be the direct cause for the typical clinical symptoms of visual dysfunction in MS patients.

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