Endothelial nitric-oxide synthase overexpression rescues cerebral blood flow and cerebrovascular reactivity in diabetic brain
Saurav B Chandra 1 , Sumathy Mohan 2 , Preethi Janardhanan 2 , Kaiwalya S Deo 1 , Eric R Muir 1 , and Timothy Q Duong 1
Research Imaging Institute, UT Health
Science Center, San Antonio, TX, United States,
UT Health Sc. Center, San Antonio, TX, United States
Reduced bioavailability of nitric oxide plays a crucial
role in endothelial dysfunction in diabetes. The goal of
this study was to investigate the effect of eNOS
overexpression on cerebral blood flow (CBF) and
cerebrovascular reactivity (CR) in diabetic mice,
eNOS-overexpressed (TgeNOS) mice, Akita diabetic (Ins2
Akita) mice, and a genetic cross of TgeNOS⨂Ins2 Akita.
We hypothesized that eNOS overexpression rescues CBF and
CR dysfunction in the diabetic brain.
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