Abstract #2320
Measuring brain lactate with 1 H-MRS during hypoglycemia in humans; preliminary results
Evita C. Wiegers 1 , Hanne M.M. Rooijackers 2 , Cees J. Tack 2 , Arend Heerschap 1 , Bastiaan E. de Galan 2 , and Marinette van der Graaf 1,3
1
Radiology and Nuclear Medicine, Radboud
University Medical Center, Nijmegen, Gelderland,
Netherlands,
2
Internal
Medicine, Radboud University Medical Center, Nijmegen,
Gelderland, Netherlands,
3
Pediatrics,
Radboud University Medical Center, Nijmegen, Gelderland,
Netherlands
The effect of hypoglycemia on brain lactate content was
studied with
1
H-MRS.
Difference spectra, acquired with an interleaved
J-editing (MEGA) semi-LASER sequence, were used to
determine brain lactate levels during stable euglycemic
and hypoglycemic conditions. Furthermore, arterial blood
samples were taken to determine arterial lactate and
glucose levels. The preliminary results, obtained in
healthy volunteers, suggest that increased plasma
lactate levels during hypoglycemia are not accompanied
by an increase in lactate content in the brain.
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