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Abstract #2322

Absolute CBV and AIF from Global Recirculation Approach

Jeiran Jahani 1 , Timothy M Shepherd 1 , Glyn Johnson 1 , Valerij G Kiselev 2 , and Dmitry S Novikov 1

1 Department of Radiology, New York University School of Medicine, New York City, New York, United States, 2 Department of Radiology, Medical Physics, University Medical Center Freiburg, Freiburg, Germany

Indicator dilution techniques have been at the heart of vascular disease diagnostics for decades. The current approaches consider the first pass of the contrast and cannot account for recirculation. This complicates data interpretation as the first pass and recirculation boluses overlap. For the first time, we develop a global approach to contrast circulation within the body with account for all organs and the topology of the circulation system. This framework allows us to obtain the explicit form of contrast kinetics in individual organs. It also provides us with AIF without directly measuring it, and a practical way to map the local absolute CBV without the need for the first pass extraction.

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