Abstract #2322
Absolute CBV and AIF from Global Recirculation Approach
Jeiran Jahani 1 , Timothy M Shepherd 1 , Glyn Johnson 1 , Valerij G Kiselev 2 , and Dmitry S Novikov 1
1
Department of Radiology, New York University
School of Medicine, New York City, New York, United
States,
2
Department
of Radiology, Medical Physics, University Medical Center
Freiburg, Freiburg, Germany
Indicator dilution techniques have been at the heart of
vascular disease diagnostics for decades. The current
approaches consider the first pass of the contrast and
cannot account for recirculation. This complicates data
interpretation as the first pass and recirculation
boluses overlap. For the first time, we develop a global
approach to contrast circulation within the body with
account for all organs and the topology of the
circulation system. This framework allows us to obtain
the explicit form of contrast kinetics in individual
organs. It also provides us with AIF without directly
measuring it, and a practical way to map the local
absolute CBV without the need for the first pass
extraction.
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