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Abstract #2323

Measurement of Local Cerebral Hematocrit with MRI

Fernando Calamante 1 , Andr Ahlgren 2 , Matthias J.P. van Osch 3 , and Linda Knutsson 2

1 The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia, 2 Department of Medical Radiation Physics, Lund University, Lund, Sweden, 3 Department of Radiology, C.J. Gorter Center for high field MRI, Netherlands

The % blood-volume occupied by red-blood-cells is known as hematocrit (Hct). Whereas it is straightforward to measure Hct in large arteries (e.g. blood sample), it is very challenging to do it in microvasculature (cerebral Hct). Currently, this can only be done using invasive methods (e.g. PET, SPECT, autoradiography), but their use is very limited. Local variations in cerebral Hct have been reported in various brain abnormalities (e.g. stroke, tumours). We propose an MRI method to image cerebral Hct, which relies on combining data from two MRI measurements: one that provides Hct-weighted, and another one Hct-independent values of the same parameter.

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