Abstract #2323
Measurement of Local Cerebral Hematocrit with MRI
Fernando Calamante 1 , Andr Ahlgren 2 , Matthias J.P. van Osch 3 , and Linda Knutsson 2
1
The Florey Institute of Neuroscience and
Mental Health, University of Melbourne, Melbourne,
Victoria, Australia,
2
Department
of Medical Radiation Physics, Lund University, Lund,
Sweden,
3
Department
of Radiology, C.J. Gorter Center for high field MRI,
Netherlands
The % blood-volume occupied by red-blood-cells is known
as hematocrit (Hct). Whereas it is straightforward to
measure Hct in large arteries (e.g. blood sample), it is
very challenging to do it in microvasculature (cerebral
Hct). Currently, this can only be done using invasive
methods (e.g. PET, SPECT, autoradiography), but their
use is very limited. Local variations in cerebral Hct
have been reported in various brain abnormalities (e.g.
stroke, tumours). We propose an MRI method to image
cerebral Hct, which relies on combining data from two
MRI measurements: one that provides Hct-weighted, and
another one Hct-independent values of the same
parameter.
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