Effect of labelling plane angulation on pCASL labelling efficiency does it really matter?

Pseudo-continuous Arterial Spin Labeling (ASL) (pCASL) is emerging as a method of choice for the non-invasive measurement of tissue perfusion in research and clinical practice. It is not clear, what the effect of imperfect angulation and mis-placement will have on the labeling efficiency and consequently, on CBF estimation. Therefore this work aims to address this question by simulation and in vivo experiment and quantitatively assess the effect of the angulation of the labeling plane on pCASL labeling efficiency.

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