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Abstract #2330

Improving Look & Locker readout for pCASL using a variable Flip Angle sweep

Marco Castellaro 1 , Alessandra Bertoldo 1 , Denis Peruzzo 2 , Filippo Arrigoni 2 , and Matthias Van Osch 3

1 Department of Information Engineering, University of Padova, Padova, Italy, 2 Department of Neuroimaging, Research institute IRCCS "E. Medea", Bosisio Parini, Lecco, Italy, 3 C.J. Gorter Center for High Field MRI, Radiology, Leiden University Medical Center, Leiden, Netherlands

Arterial spin labelling (ASL) is a technique that permits to estimate perfusion non-invasively. The readout phase of ASL sequence can follow several schemes. In particular, to sample the entire kinetic curve of the inflowing blood the use of a Look&Locker (LL) read-out has been proposed. The LL approach suffers, however, from a progressively lower Signal-to-Noise Ratio (SNR) for later post-labeling delays (PLDs) due to T1-relaxation and the fact that the label experienced multiple excitation pulses. This work presents an approach to optimize the SNR over all PLDs of a LL read-out scheme by introducing a variable flip-angle (FA) sweep.

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