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Abstract #2329

Comparative Assessment of SAGE and GRE DSC Perfusion: Initial Assessment in a Stroke Cohort

Shalini A. Amukotuwa 1,2 , Fernando Calamante 2 , and Roland Bammer 1

1 Department of Radiology, Stanford University, Stanford, CA, United States, 2 The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia

Combined spin- and gradient-echo (SAGE) dynamic susceptibility contrast (DSC) perfusion-weighted imaging (PWI) has considerable benefits over conventional single-echo spin-echo (SE) or gradient-echo (GRE) DSC PWI. However, mismatch criteria are based on GRE DSC PWI. Our aim is to investigate the comparability of the second gradient-echo of SAGE with GRE DSC PWI in patients with suspected stroke. Our findings indicate that, with matching scan parameters, the SAGE 2nd gradient-echo yields comparable results to conventional GRE DSC PWI; therefore SAGE data can be calibrated with GRE DSC data, and postprocessing algorithms optimized through previous clinical trials can be applied to SAGE.

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