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Abstract #2328

Cell Size Imaging

Natenael B Semmineh 1 , Ashley M Stokes 1 , John C Gore 1 , and C Chad Quarles 1

1 Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States

Recently, we demonstrated that T2* and T2 weighted contrast enhanced MRI signals, when acquired at contrast agent equilibrium, are predominantly influenced by the cellular properties of tissue. We now propose a novel imaging approach that utilizes these T2* and T2 effects to derive an estimate of mean cell size in a voxel. Using simulations, in vitro and in vivo studies we demonstrate that the ratio of ΔR2* and ΔR2 is related to cellular size and may be used to estimate mean cell size in a voxel.

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