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Abstract #2335

Conversion of the arterial input function using accelerated dual-contrast EPIK: a multi-modality MR-PET study

Liliana Lourenco Caldeira 1 , Seong Dae Yun 1 , Nuno Andr da Silva 1 , Christian Filss 1 , and N. Jon Shah 1,2

1 Institute of Neuroscience and Medicine (4), Forschungszentrum Juelich, Jlich, Germany, 2 RWTH Aachen University, Faculty of Medicine, Department of Neurology, JARA, Aachen, Germany

The arterial input function (AIF) is essential for quantification in MRI and PET imaging. The ground truth for AIF estimation is arterial cannulation, which is a difficult procedure. Alternatively, an image-derived AIF can be estimated using MRI and/or PET images, but a reasonable temporal resolution of dynamic image series is necessary (<2s). In PET, high temporal resolution is limited (>5s) and images are rather noisy. Here, we propose a method to combine simultaneous MR-PET data to estimate the AIF. The MR AIF is based on an EPI with keyhole (EPIK) sequence and then can be converted to a PET AIF.

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