Abstract #2335
Conversion of the arterial input function using accelerated dual-contrast EPIK: a multi-modality MR-PET study
Liliana Lourenco Caldeira 1 , Seong Dae Yun 1 , Nuno Andr da Silva 1 , Christian Filss 1 , and N. Jon Shah 1,2
1
Institute of Neuroscience and Medicine (4),
Forschungszentrum Juelich, Jlich, Germany,
2
RWTH
Aachen University, Faculty of Medicine, Department of
Neurology, JARA, Aachen, Germany
The arterial input function (AIF) is essential for
quantification in MRI and PET imaging. The ground truth
for AIF estimation is arterial cannulation, which is a
difficult procedure. Alternatively, an image-derived AIF
can be estimated using MRI and/or PET images, but a
reasonable temporal resolution of dynamic image series
is necessary (<2s). In PET, high temporal resolution is
limited (>5s) and images are rather noisy. Here, we
propose a method to combine simultaneous MR-PET data to
estimate the AIF. The MR AIF is based on an EPI with
keyhole (EPIK) sequence and then can be converted to a
PET AIF.
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