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Abstract #2340

A modified deconvolution method to quantify brain tumour haemodynamic parameters in the presence of contrast agent extravasation.

Thas Roque 1 , Amit Mehndiratta 2 , Lawrence Kenning 3 , Martin Lowry 3 , and Michael Chappell 1

1 Institute of Biomedical Engineering IBME, University of Oxford, Oxford, Oxfordshire, United Kingdom, 2 Centre for Biomedical Engineering, Indian Institute of Technology Delhi, New Delhi, India, 3 Centre for MR investigations CMRI, University of Hull, Hull, United Kingdom

In order to derive brain haemodynamic parameters such as CBF and the residue function, DSC-MRI analysis typically involves a deconvolution problem. If the blood-brain barrier is disrupted, these parameters are artificially modified due to contrast agent (CA) leakage. In this work, a model free, non-parametric deconvolution method was modified (mCPI) to account for CA leakage. In simulations, mCPI accurately estimated haemodynamic parameters in the presence of CA leakage. Glioma clinical data analysis yielded different shapes of residue function for different tumour areas, which permits assessment of flow heterogeneity within and around the tumour.

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