A modified deconvolution method to quantify brain tumour haemodynamic parameters in the presence of contrast agent extravasation.
Thas Roque 1 , Amit Mehndiratta 2 , Lawrence Kenning 3 , Martin Lowry 3 , and Michael Chappell 1
Institute of Biomedical Engineering IBME,
University of Oxford, Oxford, Oxfordshire, United
for Biomedical Engineering, Indian Institute of
Technology Delhi, New Delhi, India,
for MR investigations CMRI, University of Hull, Hull,
In order to derive brain haemodynamic parameters such as
CBF and the residue function, DSC-MRI analysis typically
involves a deconvolution problem. If the blood-brain
barrier is disrupted, these parameters are artificially
modified due to contrast agent (CA) leakage. In this
work, a model free, non-parametric deconvolution method
was modified (mCPI) to account for CA leakage. In
simulations, mCPI accurately estimated haemodynamic
parameters in the presence of CA leakage. Glioma
clinical data analysis yielded different shapes of
residue function for different tumour areas, which
permits assessment of flow heterogeneity within and
around the tumour.
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