Abstract #2341
In Vitro and In Vivo Measurement of Pseudo Continuous Arterial Spin Labeling Efficiency
Adam Michael Bush 1 , Gregory Lee 2 , Matt Borzage 1 , Vincent Schmithorst 2 , Scott Holland 2 , and John Wood 1
1
Children's Hospital Los Angeles USC, Los
Angeles, California, United States,
2
Pediatric
Neuroimaging Research Consortium, Cincinnati Children's
Hospital Medical Center, Cincinnati, Ohio, United States
To quantitatively assess PCASL labeling efficiency (LE)
we used a technique that labels blood in the feeding
vessels and measures the perfusion signal a short
distance further downstream in the blood pool. We
measured LE in a flow phantom and in-vivo, then compared
these results to Bloch simulations of PCASL efficiency.
Phantom LE measurements agree with Bloch predictions of
LE with respect velocity. Generally, in-vivo LE could be
explained by arterial velocity, however, in several
in-vivo measurements, LE variability was significantly
lower than predicted by velocity alone. These data
suggest measurement of LE may be necessary for accurate
ASL quantification.
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