Abstract #2342
Experimental assessment of pCASL labeling efficiency in the peripheral vasculature
Erin K Englund 1 , Zachary B Rodgers 1 , Thomas F Floyd 2 , and Felix W Wehrli 1
1
Department of Radiology, University of
Pennsylvania, Philadelphia, PA, United States,
2
Department
of Anesthesiology, Stony Brook University, Stony Brook,
NY, United States
The blood flow waveform in the peripheral circulation
differs substantially from that of the central
vasculature. During baseline flow conditions, blood
flows both antegrade and retrograde. During reactive
hyperemia, average blood flow increases substantially,
although the maximum velocity remains relatively
unchanged. Here, we explored the implications of varying
blood flow velocity at baseline and during reactive
hyperemia on pCASL labeling efficiency by measuring
signal in the femoral artery during an
ischemia-reperfusion paradigm. Results suggest average
labeling efficiency to be unaffected by changes in
average blood flow velocity, likely because the maximum
velocity is relatively unchanged.
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