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Abstract #2342

Experimental assessment of pCASL labeling efficiency in the peripheral vasculature

Erin K Englund 1 , Zachary B Rodgers 1 , Thomas F Floyd 2 , and Felix W Wehrli 1

1 Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2 Department of Anesthesiology, Stony Brook University, Stony Brook, NY, United States

The blood flow waveform in the peripheral circulation differs substantially from that of the central vasculature. During baseline flow conditions, blood flows both antegrade and retrograde. During reactive hyperemia, average blood flow increases substantially, although the maximum velocity remains relatively unchanged. Here, we explored the implications of varying blood flow velocity at baseline and during reactive hyperemia on pCASL labeling efficiency by measuring signal in the femoral artery during an ischemia-reperfusion paradigm. Results suggest average labeling efficiency to be unaffected by changes in average blood flow velocity, likely because the maximum velocity is relatively unchanged.

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