Improving the reproducibility of labeling-efficiency measurements in vivo in pseudo-continuous arterial spin labeling

Although pseudo-continuous arterial spin labeling (pCASL) has become the recommended choice for non-invasive perfusion measurements in the human brain, perfusion quantification is still challenging. For instance, the detected ASL signal change, and hence the estimated perfusion value, is directly proportional to the labeling efficiency . Purpose of the current study is to investigate requirements for a high reproducibility of measurements. It is shown that this property can be improved significantly, if both the slice position and the sampling rate of the experiment are optimized. Thereby, procedural details towards measuring robustly in one additional pre-scan were obtained.

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