Abstract #2344
Optimization of phase-contrast MRI for the quantification of whole-brain cerebral blood flow
Shin-Lei Peng 1,2 , Pan Su 1,3 , Fu-Nien Wang 2 , Yan Cao 4 , Rong Zhang 5 , Hanzhang Lu 1,3 , and Peiying Liu 1
1
Advanced Imaging Research Center, University
of Texas Southwestern Medical Center, Dallas, TX, United
States,
2
Department
of Biomedical Engineering and Environmental Sciences,
National Tsing Hua University, Hsinchu, Taiwan,
3
Biomedical
Engineering Graduate Program, UT Southwestern Medical
Center, TX, United States,
4
Department
of Mathematical Sciences, University of Texas at Dallas,
Richardson, TX, United States,
5
Institute
for Exercise and Environmental Medicine, Texas Health
Presbyterian Hospital Dallas, Dallas, TX, United States
PC-MRI is a noninvasive technique for quantifying
whole-brain CBF. However, PC-MRI measured velocity map
is susceptible to partial voluming, leading to biases in
CBF estimation. This work firstly aimed to optimize
in-plane resolution of PC-MRI for CBF quantification.
Furthermore, we assessed effects of non-perpendicular
imaging slice orientation on CBF quantification. Results
showed in-plane resolution of 0.5 mm could serve as an
optimal protocol for quantifying whole-brain CBF.
Moreover, non-perpendicular positioning of the imaging
slice on the targeted artery could result in
overestimated CBF. But if the slice orientation is
within 10X of the ideal angulation, the bias is
negligible.
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