Abstract #2345
Optimal Sampling Design in Quantitative DCE MRI
Ina Nora Kompan 1,2 and Matthias Guenther 1,2
1
Fraunhofer MEVIS, Bremen, Bremen, Germany,
2
mediri
GmbH, Heidelberg, Baden-Wrttemberg, Germany
Pharmacokinetic (PK) modeling is used in DCE MRI to
quantify tissue physiology. Here, optimal sampling
design based on the Fisher information approach is
applied to the Tofts model to find important time points
for model fitting. For an assumed underlying parameter
distribution it is found that fast sampling during the
first two minutes after contrast agent onset is
important for fitting accuracy. It is also shown that
optimal sampling schemes outperform equidistant sampling
schemes for small number of sampling points with respect
to fitting accuracy.
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