Meeting Banner
Abstract #2345

Optimal Sampling Design in Quantitative DCE MRI

Ina Nora Kompan 1,2 and Matthias Guenther 1,2

1 Fraunhofer MEVIS, Bremen, Bremen, Germany, 2 mediri GmbH, Heidelberg, Baden-Wrttemberg, Germany

Pharmacokinetic (PK) modeling is used in DCE MRI to quantify tissue physiology. Here, optimal sampling design based on the Fisher information approach is applied to the Tofts model to find important time points for model fitting. For an assumed underlying parameter distribution it is found that fast sampling during the first two minutes after contrast agent onset is important for fitting accuracy. It is also shown that optimal sampling schemes outperform equidistant sampling schemes for small number of sampling points with respect to fitting accuracy.

This abstract and the presentation materials are available to members only; a login is required.

Join Here