Optimal Sampling Design in Quantitative DCE MRI

Pharmacokinetic (PK) modeling is used in DCE MRI to quantify tissue physiology. Here, optimal sampling design based on the Fisher information approach is applied to the Tofts model to find important time points for model fitting. For an assumed underlying parameter distribution it is found that fast sampling during the first two minutes after contrast agent onset is important for fitting accuracy. It is also shown that optimal sampling schemes outperform equidistant sampling schemes for small number of sampling points with respect to fitting accuracy.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.