Abstract #2348
Correcting for bolus delay and dispersion in the AIF using a constrained local AIF (LAIF) model
Chong Duan 1 , Jesper F Kallehauge 2 , Carlos J Perez-Torres 3 , Kari Tanderup 4,5 , Larry Bretthorst 3 , Joseph JH Ackerman 1,3 , and Joel R Garbow 3
1
Chemistry, Washington University, Saint
Louis, Missouri, United States,
2
Medical
Physics, Aarhus University, Aarhus, Denmark,
3
Radiology,
Washington University, Saint Louis, Missouri, United
States,
4
Radiation
Oncology, Washington University, Saint Louis, Missouri,
United States,
5
Oncology,
Aarhus University, Aarhus, Denmark
Many DCE-MRI data models employ a directly determined
upstream arterial input function (AIF). The actual AIF
at the capillary inlet of any given region of interest
is both delayed and dispersed compared with the upstream
AIF measured in a major feeding vessel. We build a
constrained local AIF (cLAIF) model to better model
DCE-MRI data, accounting for both delay and dispersion.
Voxel-wise model selection analyses show the cLAIF is
preferred over the upstream measured AIF for ~80% of the
voxels.
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