Abstract #2347
The Effect of Dynamic Contrast Enhanced Acquisition Duration on Estimated Pharmacokinetic Parameters: Study of Simulated and Real Data
Moran Artzi 1,2 , Gilad Liberman 1,3 , Guy Nadav 1,4 , Deborah T Blumenthal 5 , Orna Aizenstein 1 , and Dafna Ben Bashat 1,6
1
Functional Brain Center, Tel Aviv Sourasky
Medical Center, Tel Aviv, Israel,
2
Sackler
Faculty of Medicine, Tel Aviv University, Tel Aviv,
Israel,
3
Department
of Chemical Physics, Weizmann Institute, Rehovot,
Israel,
4
Functional
Brain Center, Tel Aviv University, Tel Aviv, Israel,
5
Neuro-Oncology
Service, Tel Aviv Sourasky Medical Center, Tel Aviv,
Israel,
6
Sackler
Faculty of Medicine and Sagol School of Neuroscience,
Tel Aviv University, Tel Aviv, Israel
The effect of dynamic contrast enhancement (DCE)
acquisition duration on the pharmacokinetic-parameters
estimation was investigated using simulated and real
data obtained from seven patients with glioblastoma. DCE
parameters were estimated using DUSTER, a method for DCE
Up-Sampled-Temporal-Resolution, and with scan duration
from 6 to 35 minutes. This study suggests an optimized
protocol that can be easily implemented in routing
clinical setup. Scan duration of 20 minutes was found to
be sufficient to obtain reliable and accurate
pharmacokinetic parameters from DCE, especially kep.
Results emphasize that care should be taken when using
model selection with data acquired with short scan
duration.
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