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Abstract #2347

The Effect of Dynamic Contrast Enhanced Acquisition Duration on Estimated Pharmacokinetic Parameters: Study of Simulated and Real Data

Moran Artzi 1,2 , Gilad Liberman 1,3 , Guy Nadav 1,4 , Deborah T Blumenthal 5 , Orna Aizenstein 1 , and Dafna Ben Bashat 1,6

1 Functional Brain Center, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, 2 Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, 3 Department of Chemical Physics, Weizmann Institute, Rehovot, Israel, 4 Functional Brain Center, Tel Aviv University, Tel Aviv, Israel, 5 Neuro-Oncology Service, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, 6 Sackler Faculty of Medicine and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel

The effect of dynamic contrast enhancement (DCE) acquisition duration on the pharmacokinetic-parameters estimation was investigated using simulated and real data obtained from seven patients with glioblastoma. DCE parameters were estimated using DUSTER, a method for DCE Up-Sampled-Temporal-Resolution, and with scan duration from 6 to 35 minutes. This study suggests an optimized protocol that can be easily implemented in routing clinical setup. Scan duration of 20 minutes was found to be sufficient to obtain reliable and accurate pharmacokinetic parameters from DCE, especially kep. Results emphasize that care should be taken when using model selection with data acquired with short scan duration.

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